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1980 Metcalfe, IL et al
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Pulmonary surfactant-associated proteins: their role in the expression of surface
activity. Am Physio Soc. 1980:34-41.
Summary: An extract of calf surfactant has equal biophysical and biologic activity
to natural surfactant.
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1983 Egan, EA et al
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Natural and artificial lung surfactant replacement therapy in premature lambs. J
Appl Physiol. 1983;55:875-883.
Summary: Instillation of calf surfactant extract at birth induces near normal respiratory
function in lambs.
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1983 Smyth, JA et al
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Hyaline membrane disease treated with bovine surfactant. Peds. 1983;71:913-917.
Summary: Six preterm infants with severe RDS were treated with extract of calf surfactant
showing improved arterial oxygenation lasting up to 24 hours.
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1992 Cummings, JJ et al
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A controlled clinical comparison of four different surfactant preparations in surfactant-deficient
preterm lambs. Amer Rev Resp Dis. 1992;145:999-1004.
Summary: Lambs with no endogenous surfactant had better and more sustained response
with lower mortality following prophylaxis with Infasurf than with Exosurf or Survanta.
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1992 Hall, SB et al
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Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants.
Am Rev Respir Dis. 1992;145:24-30.
Summary: The increased concentration of hydrophobic surfactant apoproteins SP-B
and SP-C in Infasurf explains its greater biophysical and biological activity compared
to Exosurf and Survanta.
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1993 Seeger, W et al
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Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant
preparations. Eur Respir J. 1993;6:971-977.
Summary: Infasurf is more potent and less vulnerable to inhibition than Survanta
or Curosurf because of the high SP-B content.
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1995 Mizuno, K et al
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Surfactant protein-B supplementation improves in vitro function of a modified natural
surfactant. Ped Research. 1995;37:271-276.
Summary: SP-B level in Survanta is sub-threshold. Its low SP-B is the reason for
less biologic activity than Infasurf.
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2002 Notter, RH et al
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Component-specific surface and physiological activity in bovine-derived lung surfactants.
Chem Phys Lipids. 2002;114:21-34.
Summary: Infasurf’s higher SP-B content is a crucial factor in surface activity
and its ability to improve pulmonary mechanics.
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2002 King, DM et al
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Bulk shear viscosities of endogenous and exogenous lung surfactants. Am J Physiol
Lung Cell Mol Physiol. 2002;282:L277-84.
Summary: Infasurf and natural surfactant have lower viscosities at any given shear
rate and concentration versus Survanta or Exosurf.
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